Rabbit anti-Human RAMP1 Polyclonal Antibody | anti-RAMP1 antibody

RAMP1 Rabbit Polyclonal

Cat. Num. AAA7603330

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RAMP1; Polyclonal Antibody; RAMP1 Rabbit Polyclonal; anti-RAMP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 126

• Applicable Applications for anti-RAMP1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Receptor (G protein-coupled) activity modifying protein 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat heart tissue slide using MBS7603330 (RAMP1 Antibody) at dilution of 1:100)

Western Blot (WB)

(HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7603330 (RAMP1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 816197638
• NCBI GeneID: 10267
• NCBI Accession #: NP_001295282.1
• NCBI GenBank Nucleotide #: NM_001308353.1
• Molecular Weight: 16,988 Da
• NCBI Official Full Name: receptor activity-modifying protein 1 isoform 2
• NCBI Official Synonym Full Names: receptor activity modifying protein 1
• NCBI Official Symbol: RAMP1
• NCBI Protein Information: receptor activity-modifying protein 1
• UniProt Protein Name: Receptor activity-modifying protein 1
• Protein Family: Receptor activity-modifying protein
• UniProt Gene Name: RAMP1
• UniProt Synonym Gene Names: CRLR activity-modifying protein 1
• UniProt Entry Name: RAMP1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Uniprot Description

RAMP1: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Belongs to the RAMP family.

Protein type: Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q36-q37.1

Cellular Component: cell surface; extracellular space; integral to plasma membrane; intracellular; plasma membrane; receptor complex

Molecular Function: calcitonin receptor activity; calcitonin receptor binding; coreceptor activity; protein binding; protein transporter activity; receptor activity

Biological Process: angiogenesis; calcium ion transport; G-protein coupled receptor protein signaling pathway; intracellular protein transport; positive regulation of cAMP biosynthetic process; positive regulation of protein amino acid glycosylation; protein transport; receptor internalization; regulation of G-protein coupled receptor protein signaling pathway