Rabbit TGF-beta 2 Antibody | anti-TGF-beta 2 antibody

Rabbit anti TGF-b2 antibody

Cat. Num. AAA462143

• Gene Names: TGFB2; MGC116892; TGF-beta2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: The Rabbit IgG is purified by Epitope affinity purification
• Synonyms: TGF-beta 2; Rabbit anti TGF-b2 antibody; Rabbit anti-TGFb2; anti-TGF-beta 2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Specificity: This antibody recognizes ~13 kDa of TGF-beta 2, not TGF-beta 1 and less extense of TGF-beta 3. It reacts with human, rat and mouse. The other species are not tested.
• Purity/Purification: The Rabbit IgG is purified by Epitope affinity purification
• Form/Format: This affinity purified antibody is supplied in sterile Phosphate-buffered saline (pH7.2) containing antibody stabilizer.
• Concentration: Size: 100 ug/200 ul (varies by lot)

• Applicable Applications for anti-TGF-beta 2 antibody: ELISA, Western Blot, Immunohistochemistry
• Application Notes: Western Blot: 0.1-1 ug/ml; ELISA: 0.01-0.1 ug/ml; Immunoprecipitation: 2-5 ug/ml; Immunohistochemistry: 2-5 ug/ml
• Antigen Preparation: A synthetic peptide derived from C-terminus of human TGF-beta 2 protein.
• Positive Control: Placenta
• Cellular Location: Membrane and cytoplasmic
• Preparation and Storage: The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. Upon initial thawing, apportion into working aliquots and store at -70 degree C for up to six months. The antibodies can be stored at 2 degree C-8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 48429157
• NCBI GeneID: 7042
• NCBI Accession #: P61812.1
• NCBI GenBank Nucleotide #: P61812
• UniProt Accession #: P61812; P08112; Q15579; Q15581; Q4VAV9; B4DKC5; Q59EG9
• Molecular Weight: ~13 kDa
• NCBI Official Full Name: Transforming growth factor beta-2
• NCBI Official Synonym Full Names: transforming growth factor, beta 2
• NCBI Official Symbol: TGFB2
• NCBI Official Synonym Symbols: MGC116892; TGF-beta2
• NCBI Protein Information: transforming growth factor beta-2; G-TSF; cetermin; polyergin; TGF-beta-2; OTTHUMP00000037528; OTTHUMP00000037529; BSC-1 cell growth inhibitor; glioblastoma-derived T-cell suppressor factor
• UniProt Protein Name: Transforming growth factor beta-2
• UniProt Gene Name: TGFB2
• UniProt Entry Name: TGFB2_HUMAN

NCBI Description

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Uniprot Description

Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

Subunit structure: Homodimer; disulfide-linked. Interacts with ASPN. Ref.11

Subcellular location: Secreted.

Involvement in disease: Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.

Sequence similarities: Belongs to the TGF-beta family.