Western Blot (WB)
(N=normal, R=retinopathy of prematurity, V=VEGF/rho transgenic miceWestern blot analysis of extracts of various cell lines, using IL17A antibody.)
Rabbit IL17A Antibody | anti-IL17A antibody
IL17A Antibody
Gene Names
IL17A; IL17; CTLA8; IL-17; CTLA-8; IL-17A
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
Affinity purification
Synonyms
IL17A; IL17A Antibody; CTLA8; IL-17; IL-17A; IL17; anti-IL17A antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Purity/Purification
Affinity purification
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Sequence Length
155
Applicable Applications for anti-IL17A antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
WB: 1:200-1:500
IHC: 1:50-1:200
IF: 1:20-1:50
IHC: 1:50-1:200
IF: 1:20-1:50
Immunogen
Recombinant protein of human IL17A
Preparation and Storage
Store at-20 degree C or -80 degree C. Avoid freeze/thaw cycles.
Western Blot (WB)
(N=normal, R=retinopathy of prematurity, V=VEGF/rho transgenic miceWestern blot analysis of extracts of various cell lines, using IL17A antibody.)
Western Blot (WB)
(N=normal, R=retinopathy of prematurity, V=VEGF/rho transgenic miceWestern blot analysis of extracts of various cell lines, using IL17A antibody.)
Immunofluorescence (IF)
(Immunofluorescent analysis of eyeball-dapi of mouse.)
Immunofluorescence (IF)
(Immunofluorescent analysis of eyeball-dapi of mouse.)
Immunofluorescence (IF)
(Immunofluorescent analysis of eyeball of mouse using IL17A RabpAb.)
Immunofluorescence (IF)
(Immunofluorescent analysis of eyeball of mouse using IL17A RabpAb.)
Related Product Information for anti-IL17A antibody
IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage (1, 2). IL-17A stimulates the production of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity (1, 2). IL-17A is intimately involved in mucosal immunity against bacterial infections (1, 3) and has a putative role in some autoimmune disorders (1, 4). IL-17A effects appear to be exerted primarily through binding to the IL-17RA (5). IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-kappaB pathways (3, 4, 6). Phosphorylation of some Jaks and Stats has been observed.
Product Categories/Family for anti-IL17A antibody
References
1. Kolls, J.K. and Lindén, A. (2004) Immunity 21, 467-76. 2. Liang, S.C. et al. (2006) J Exp Med 203, 2271-9. 3. Dubin, P.J. and Kolls, J.K. (2008) Immunol Rev 226, 160-71. 4. Zrioual, S. et al. (2009) J Immunol 182, 3112-20. 5. Wright, J.F. et al. (2008) J Immunol 181, 2799-805. 6. Rahman, M.S. et al. (2006) J Immunol 177, 4064-71.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18kDa
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; CTLA-8; IL-17A
NCBI Protein Information
interleukin-17A
UniProt Protein Name
Interleukin-17A
Protein Family
UniProt Gene Name
IL17A
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8
NCBI Description
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Uniprot Description
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Research Articles on IL17A
Similar Products
Product Notes
The IL17A il17a (Catalog #AAA8500025) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL17A Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IL17A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:200-1:500 IHC: 1:50-1:200 IF: 1:20-1:50. Researchers should empirically determine the suitability of the IL17A il17a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL17A, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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