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Western Blot (WB) (Western Blot analysis of extracts from MCF-7 cells using SLC24A6 antibody.)

Rabbit anti-Human SLC24A6 Antibody | anti-SLC24A6 antibody

Rabbit SLC24A6 Antibody

Gene Names
SLC24A6; NCLX; NCKX6
Reactivity
Human
Purity
Immunogen affinity purified
Synonyms
SLC24A6; Rabbit SLC24A6 Antibody; FLJ22233; Na(+)/K(+)/Ca(2+) exchange protein 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; NCKX6; NCKX6_HUMAN; NCLX; Slc24a6; Sodium/potassium/calcium exchanger; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6; Solute carrier family 24 member 6; anti-SLC24A6 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Specificity
SLC24A6 Antibody detects endogenous levels of total SLC24A6
Purity/Purification
Immunogen affinity purified
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Sequence Length
584
Application Notes
WB 1:500~1:1000
ELISA(peptide) 1:20000-1:40000

Optimal dilutions/concentrations should be determined by the end user.
Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Immunogen
A synthesized peptide
Function
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
Preparation and Storage
Store at -20 °C.Stable for 12 months from date of receipt

Western Blot (WB)

(Western Blot analysis of extracts from MCF-7 cells using SLC24A6 antibody.)

Western Blot (WB) (Western Blot analysis of extracts from MCF-7 cells using SLC24A6 antibody.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
sodium/potassium/calcium exchanger 6, mitochondrial
NCBI Official Synonym Full Names
solute carrier family 24 (sodium/lithium/calcium exchanger), member 6
NCBI Official Symbol
SLC24A6
NCBI Official Synonym Symbols
NCLX; NCKX6
NCBI Protein Information
sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 member 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; sodium/calcium exchanger protein, mitochondrial; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
UniProt Protein Name
Sodium/potassium/calcium exchanger 6, mitochondrial
UniProt Gene Name
SLC24A6
UniProt Synonym Gene Names
NCKX6; NCLX
UniProt Entry Name
NCKX6_HUMAN

NCBI Description

SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]

Uniprot Description

SLC24A6: Transports Ca(2+) in exchange for either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral; Calcium-binding

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: mitochondrial crista; plasma membrane; sarcolemma

Molecular Function: protein homodimerization activity; calcium:sodium antiporter activity

Biological Process: mitochondrial calcium ion homeostasis; cytosolic calcium ion homeostasis; response to stimulus; ion transport; glucose homeostasis; regulation of insulin secretion; transmembrane transport; mitochondrial calcium ion transport

Research Articles on SLC24A6

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Product Notes

The SLC24A6 slc24a6 (Catalog #AAA004052) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit SLC24A6 Antibody reacts with Human and may cross-react with other species as described in the data sheet. WB 1:500~1:1000 ELISA(peptide) 1:20000-1:40000 Optimal dilutions/concentrations should be determined by the end user. Researchers should empirically determine the suitability of the SLC24A6 slc24a6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC24A6, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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