Rabbit anti-Human LRRK2 Antibody | anti-LRRK2 antibody

Rabbit anti LRRK2 antibody

Cat. Num. AAA462071

• Gene Names: LRRK2; PARK8; RIPK7; ROCO2; AURA17; DARDARIN
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: The Rabbit IgG is purified by Epitope Affinity Purification.
• Synonyms: LRRK2; Rabbit anti LRRK2 antibody; Rabbit anti-LRRK2; Leucine-Rich Repeat Kinase 2; PARK8; ROCO2; Dardarin; BC300-267; Parkinson disease (autosomal dominant) 8; anti-LRRK2 antibody

• Host: Rabbit
• Reactivity: Human
• Specificity: This antibody recognizes ~285 kDa of human LRRK2 protein. The other species are not tested
• Purity/Purification: The Rabbit IgG is purified by Epitope Affinity Purification.
• Form/Format: This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
• Concentration: Size: 100 ug/200 ul (varies by lot)

• Applicable Applications for anti-LRRK2 antibody: ELISA, Western Blot, Immunohistochemistry
• Application Notes: Western Blot: 0.1-1 ug/ml; ELISA: 0.01-0.1 ug/ml; Immunoprecipitation: 2-5 ug/ml
• Antigen Preparation: A synthetic peptide corresponding to C-terminus of human LRRK2.
• Positive Control: LRRK2 Transfected HEK293 cell lysate
• Preparation and Storage: The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Testing Data

Related Product Information for anti-LRRK2 antibody

The leucine-rich repeat kinase family (LRKK) proteins are consists of an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40. Various genes and loci (alpha-synuclein/PARK1 and 4, parkin/PARK2, UCH-L1/PARK5, PINK1/PARK6, DJ-1/PARK7, LRRK2/PARK8, synphilin-1 and NR4A2) are associated to Parkinson's Disease (PD). LRRK2 may play an important role as a therapeutic target for treatment of PD (5).

References

Melrose, HL, et al. A comparative analysis of leucine-rich repeat kinase 2 (LRRK2) expression in mouse brain and Lewy Body disease. Neurosci. 147: 1047-1058 (2007)

NCBI and Uniprot Product Information

• NCBI GI #: 171846278
• NCBI GeneID: 120892
• NCBI Accession #: NP_940980.3
• NCBI GenBank Nucleotide #: NM_198578.3
• UniProt Accession #: Q17RV3; Q5S007; Q6MZN9
• Molecular Weight: 285 kDa
• NCBI Official Full Name: leucine-rich repeat serine/threonine-protein kinase 2
• NCBI Official Synonym Full Names: leucine-rich repeat kinase 2
• NCBI Official Symbol: LRRK2
• NCBI Official Synonym Symbols: PARK8; RIPK7; ROCO2; AURA17; DARDARIN
• NCBI Protein Information: leucine-rich repeat serine/threonine-protein kinase 2; OTTHUMP00000179167; augmented in rheumatoid arthritis 17
• UniProt Protein Name: Leucine-rich repeat kinase 2
• Protein Family: Leucine-rich repeat serine/threonine-protein kinase
• UniProt Gene Name: LRRK2
• UniProt Entry Name: Q17RV3_HUMAN

NCBI Description

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq]

Uniprot Description

Sequence similarities: Belongs to the protein kinase superfamily. RuleBase RU000305