Rabbit Lysine-specific demethylase 5C (KDM5C) ELISA Kit | KDM5C elisa kit

Rabbit Lysine-specific demethylase 5C (KDM5C) ELISA Kit

Cat. Num. AAA7216020

• Gene Names: KDM5C; MRXJ; SMCX; MRX13; MRXSJ; XE169; MRXSCJ; JARID1C; DXS1272E
• Reactivity: Rabbit
• Synonyms: Lysine-specific demethylase 5C (KDM5C); Rabbit Lysine-specific demethylase 5C (KDM5C) ELISA Kit; KDM5C elisa kit

• Reactivity: Rabbit

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for KDM5C elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 543887186
• NCBI GeneID: 8242
• NCBI Accession #: NP_001269551.1
• NCBI GenBank Nucleotide #: NM_001282622.1
• Molecular Weight: 175,592 Da
• NCBI Official Full Name: lysine-specific demethylase 5C isoform 3
• NCBI Official Synonym Full Names: lysine (K)-specific demethylase 5C
• NCBI Official Symbol: KDM5C
• NCBI Official Synonym Symbols: MRXJ; SMCX; MRX13; MRXSJ; XE169; MRXSCJ; JARID1C; DXS1272E
• NCBI Protein Information: lysine-specific demethylase 5C; protein SmcX; selected cDNA on X; Smcy homolog, X-linked; Smcx homolog, X chromosome; histone demethylase JARID1C; mental retardation, X-linked 13; JmjC domain-containing protein SMCX; Jumonji/ARID domain-containing protein 1C; Jumonji, AT rich interactive domain 1C (RBP2-like)
• UniProt Protein Name: Lysine-specific demethylase 5C
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM5C
• UniProt Synonym Gene Names: DXS1272E; JARID1C; SMCX; XE169
• UniProt Entry Name: KDM5C_HUMAN

NCBI Description

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Uniprot Description

JARID1C: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Part of two distinct complexes, one containing E2F6, and the other containing REST. Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. Belongs to the JARID1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; Oxidoreductase; EC 1.14.11.-

Chromosomal Location of Human Ortholog: Xp11.22-p11.21

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone demethylase activity (H3-K4 specific); DNA binding; zinc ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent

Disease: Mental Retardation, X-linked, Syndromic, Claes-jensen Type