Rabbit Hexosaminidase A Alpha (HEXA) ELISA Kit | HEXA elisa kit

Rabbit Hexosaminidase A Alpha (HEXA) ELISA Kit

• Gene Names: HEXA; TSD
• Reactivity: Rabbit
• Synonyms: Hexosaminidase A Alpha (HEXA); Rabbit Hexosaminidase A Alpha (HEXA) ELISA Kit; HEXA elisa kit

• Reactivity: Rabbit

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 119598308
• NCBI GeneID: 3073
• Molecular Weight: 19,326 Da
• NCBI Official Full Name: hexosaminidase A (alpha polypeptide)
• NCBI Official Synonym Full Names: hexosaminidase subunit alpha
• NCBI Official Symbol: HEXA
• NCBI Official Synonym Symbols: TSD
• NCBI Protein Information: beta-hexosaminidase subunit alpha
• UniProt Protein Name: Beta-hexosaminidase subunit alpha
• Protein Family: Hexamerin
• UniProt Gene Name: HEXA
• UniProt Synonym Gene Names: Hexosaminidase subunit A
• UniProt Entry Name: HEXA_HUMAN

NCBI Description

This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

HEXA: Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity. Defects in HEXA are the cause of GM2-gangliosidosis type 1 (GM2G1); also known as Tay-Sachs disease. GM2- gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G1 is characterized by GM2 gangliosides accumulation in the absence of HEXA activity, leading to neurodegeneration and, in the infantile form, death in early childhood. GM2G1 has an increased incidence among Ashkenazi Jews and French Canadians in eastern Quebec. It exists in several forms: infantile (most common and most severe), juvenile and adult (late onset). Belongs to the glycosyl hydrolase 20 family.

Protein type: EC 3.2.1.52; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Glycan Metabolism - other glycan degradation; Glycan Metabolism - glycosaminoglycan degradation; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Hydrolase

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: azurophil granule; lysosomal lumen; membrane

Molecular Function: acetylglucosaminyltransferase activity; beta-N-acetylhexosaminidase activity; protein heterodimerization activity

Biological Process: carbohydrate metabolic process; chondroitin sulfate catabolic process; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; glycosphingolipid metabolic process; hyaluronan catabolic process; hyaluronan metabolic process; keratan sulfate catabolic process; keratan sulfate metabolic process; sphingolipid metabolic process

Disease: Tay-sachs Disease