Rabbit Chorion-specific transcription factor GCMb (GCM2) ELISA Kit | GCM2 elisa kit
Rabbit Chorion-specific transcription factor GCMb (GCM2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]
Uniprot Description
GCM2: Probable transcriptional regulator. Defects in GCM2 are a cause of familial isolated hypoparathyroidism (FIH); also known as autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. An autosomal recessive form of FIH also exists.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 6p23
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; metal ion binding
Biological Process: cellular calcium ion homeostasis; cellular phosphate ion homeostasis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; cell differentiation; parathyroid gland development; negative regulation of apoptosis
Disease: Hypoparathyroidism, Familial Isolated
Research Articles on GCM2
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Product Notes
The Rabbit GCM2 gcm2 (Catalog #AAA7212627) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7212627 ELISA Kit recognizes Rabbit GCM2. It is sometimes possible for the material contained within the vial of "Chorion-specific transcription factor GCMb (GCM2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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