Human quinolinate phosphoribosyltransferase ELISA Kit | QPRT elisa kit
Human Nicotinate-nucleotide pyrophosphorylase [carboxylating], QPRT ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]
Uniprot Description
QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
Protein type: EC 2.4.2.19; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytoplasm; cytosol
Molecular Function: protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity
Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; protein oligomerization; water-soluble vitamin metabolic process
Research Articles on QPRT
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Product Notes
The Human QPRT qprt (Catalog #AAA9325124) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325124 ELISA Kit recognizes Human QPRT. It is sometimes possible for the material contained within the vial of "quinolinate phosphoribosyltransferase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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