Rat pituitary tumor-transforming 1 ELISA Kit | PTTG1 elisa kit
Rat Securin, PTTG1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Securin: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family.
Protein type: Cell cycle regulation; Oncoprotein
Cellular Component: cytoplasm; nucleus
Molecular Function: heat shock protein binding; ribosome binding; cysteine protease inhibitor activity; SH3 domain binding
Biological Process: negative regulation of cell proliferation; mitosis; homologous chromosome segregation; cell division; regulation of cell growth; DNA repair; chromosome organization and biogenesis; chromosome segregation
Research Articles on PTTG1
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Product Notes
The Rat PTTG1 pttg1 (Catalog #AAA9319751) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319751 ELISA Kit recognizes Rat PTTG1. It is sometimes possible for the material contained within the vial of "pituitary tumor-transforming 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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