PTPRN recombinant protein

Recombinant Human PTPRN protein, N- MAT Tag

Cat. Num. AAA157691

• Gene Names: PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
• Purity: >90% as determined by SDS-PAGE
• Synonyms: PTPRN; Recombinant Human PTPRN protein; N- MAT Tag; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; ICA3; ICA512; PTPRN recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Human
• Construction: A DNA sequence encoding the Human PTPRN (His603-Gln979) was fused with the N-terminal MAT Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder. They are shipped out with blue ice unless customers require otherwise

Product Categories/Family for PTPRN recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 47124459
• NCBI GeneID: 5798
• UniProt Accession #: Q16849; Q08319; Q53QD6; Q6NSL1; B4DK12; F5GZS3
• Molecular Weight: 105,848 Da
• NCBI Official Full Name: PTPRN protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, N
• NCBI Official Symbol: PTPRN
• NCBI Official Synonym Symbols: IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase-like N
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRN
• UniProt Synonym Gene Names: ICA3; ICA512; R-PTP-N; ICA 512
• UniProt Entry Name: PTPRN_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Uniprot Description

PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q35-q36.1

Cellular Component: integral to membrane

Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity

Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus