Receptor-type tyrosine-protein phosphatase-like N Recombinant Protein | PTPRN recombinant protein
Recombinant Human Receptor-type tyrosine-protein phosphatase-like N
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Uniprot Description
PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q35-q36.1
Cellular Component: cell junction; cell soma; endosome; Golgi apparatus; integral to membrane; nerve terminal; perikaryon; plasma membrane; secretory granule; synapse; synaptic vesicle
Molecular Function: GTPase binding; protein binding; protein tyrosine phosphatase activity; spectrin binding
Biological Process: cytokine and chemokine mediated signaling pathway; insulin secretion; luteinization; protein amino acid dephosphorylation; response to cAMP; response to estrogen stimulus; response to insulin stimulus; response to reactive oxygen species
Research Articles on PTPRN
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Product Notes
The PTPRN ptprn (Catalog #AAA1313680) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 35-575. Partial. The amino acid sequence is listed below: VSAHGCLFDR RLCSHLEVCI QDGLFGQCQV GVGQARPLLQ VTSPVLQRLQ GVLRQLMSQG LSWHDDLTQY VISQEMERIP RLRPPEPRPR DRSGLAPKRP GPAGELLLQD IPTGSAPAAQ HRLPQPPVGK GGAGASSSLS PLQAELLPPL LEHLLLPPQP PHPSLSYEPA LLQPYLFHQF GSRDGSRVSE GSPGMVSVGP LPKAEAPALF SRTASKGIFG DHPGHSYGDL PGPSPAQLFQ DSGLLYLAQE LPAPSRARVP RLPEQGSSSR AEDSPEGYEK EGLGDRGEKP ASPAVQPDAA LQRLAAVLAG YGVELRQLTP EQLSTLLTLL QLLPKGAGRN PGGVVNVGAD IKKTMEGPVE GRDTAELPAR TSPMPGHPTA SPTSSEVQQV PSPVSSEPPK AARPPVTPVL LEKKSPLGQS QPTVAGQPSA RPAAEEYGYI VTDQKPLSLA AGVKLLEILA EHVHMSSGSF INISVVGPAL TFRIRHNEQN LSLADVTQQA GLVKSELEAQ TGLQILQTGV GQREEAAAVL PQTAHSTSPM R. It is sometimes possible for the material contained within the vial of "Receptor-type tyrosine-protein phosphatase-like N, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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