Guinea Pig Protein Tyrosine Phosphatase Receptor Type K ELISA Kit | PTPRK elisa kit
Guinea pig Protein Tyrosine Phosphatase Receptor Type K ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PTPRK: a receptor tyrosine phosphatase involved in processes including cell contact and adhesion, growth, tumor invasion, and metastasis. Is a negative regulator of EGFR signaling. Forms complexes with beta-catenin and gamma-catenin, and may modulate the phosphorylation status of beta-catenin. Absent or down-regulated in multiple melanoma cell lines and some melanoma tumors. The gene lies in a region frequently deleted in hematological neoplasms, melanomas, ovary carcinomas, and many other solid tumors. Can play a dual role of tumor suppressor and tumor promoter in mammary epithelial cells. Overexpression results in inhibition of basal proliferation and EGFR signaling in cancer cells. A key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes. TGF-beta 1 stimulates its expression, which may be important for the inhibition of keratinocyte proliferation. Belongs to the protein-tyrosine phosphatase family, receptor class 2B subfamily. Four isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.1.3.48; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 6q22.2-q22.3
Cellular Component: cell surface; adherens junction; photoreceptor outer segment; cell soma; axon; integral to plasma membrane; dendrite; integral to membrane; intercellular junction
Molecular Function: protein binding; gamma-catenin binding; beta-catenin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding
Biological Process: focal adhesion formation; negative regulation of cell proliferation; cell migration; transforming growth factor beta receptor signaling pathway; protein amino acid dephosphorylation; signal transduction; negative regulation of transcription, DNA-dependent; cell adhesion; negative regulation of cell migration; negative regulation of cell cycle
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Product Notes
The Guinea Pig PTPRK ptprk (Catalog #AAA721786) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA721786 ELISA Kit recognizes Guinea Pig PTPRK. It is sometimes possible for the material contained within the vial of "Protein Tyrosine Phosphatase Receptor Type K, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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