Human, Mouse Breast Tumor Kinase ELISA Kit | PTK6 elisa kit
Breast Tumor Kinase Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Description
Brk: a tyrosine kinase of the Src family. May function as an intracellular signal transducer in epithelial tissues. Very high level expression in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Selectively expressed in breast tumors and cell lines, and perhaps in colon and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression in mammary cells leads to EGF sensitization and results in a partially transformed phenotype. Enhances anchorage-independent growth and responsiveness to EGF. RNAi reduces proliferation in breast cancer cells. Kinase-inactive mutant indicates tumor function may be independent of catalytic function.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; ruffle
Molecular Function: ATP binding; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein tyrosine kinase activity; receptor binding
Biological Process: cell migration; cellular response to retinoic acid; ERBB2 signaling pathway; innate immune response; negative regulation of growth; negative regulation of signal transduction; peptidyl-tyrosine autophosphorylation; positive regulation of cell cycle; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of neuron projection development; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; tyrosine phosphorylation of STAT protein
Research Articles on PTK6
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Product Notes
The Human, Mouse PTK6 ptk6 (Catalog #AAA9500070) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500070 ELISA Kit recognizes Human, Mouse PTK6. It is sometimes possible for the material contained within the vial of "Breast Tumor Kinase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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