Rat Polypyrimidine tract-binding protein 1 ELISA Kit | Ptbp1 elisa kit

Rat Polypyrimidine tract-binding protein 1 ELISA Kit

Cat. Num. AAA2888074

• Gene Names: PTBP1; PTB; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; PTB-T; HNRNPI; HNRNP-I
• Reactivity: Rat
• Synonyms: Polypyrimidine tract-binding protein 1; Rat Polypyrimidine tract-binding protein 1 ELISA Kit; PTB; Heterogeneous nuclear ribonucleoprotein I; hnRNP I; Pyrimidine-binding protein; PYBP; Ptbp1; Ptb; Pybp; Tbfii; Ptbp1 elisa kit

• Reactivity: Rat
• Sequence Length: 531

• Assay Type: Sandwich
• Detection Range: 78-5000 pg/ml
• Sensitivity: 39.6 pg/mL
• Intra-Assay CV: <=5.3%
• Inter-Assay CV: <=9.8%
• Recovery: 99%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 14165466
• NCBI GeneID: 5725
• NCBI Accession #: NP_114368.1
• NCBI GenBank Nucleotide #: NM_031991.3
• Molecular Weight: 59,633 Da
• NCBI Official Full Name: polypyrimidine tract-binding protein 1 isoform c
• NCBI Official Synonym Full Names: polypyrimidine tract binding protein 1
• NCBI Official Symbol: PTBP1
• NCBI Official Synonym Symbols: PTB; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; PTB-T; HNRNPI; HNRNP-I
• NCBI Protein Information: polypyrimidine tract-binding protein 1
• UniProt Protein Name: Polypyrimidine tract-binding protein 1
• Protein Family: Polypyrimidine tract-binding protein
• UniProt Gene Name: PTBP1
• UniProt Synonym Gene Names: PTB; PTB; hnRNP I
• UniProt Entry Name: PTBP1_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP I: a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP). hnRNPs are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. Binds to the polypyrimidine tract of introns. May promote the binding of U2 snRNP to pre-mRNA. Two alternatively spliced isoforms have been described.

Protein type: RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: membrane; nucleolus; nucleoplasm

Molecular Function: poly-pyrimidine tract binding; protein binding; RNA binding

Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; mRNA processing; negative regulation of muscle cell differentiation; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of RNA splicing; nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome; RNA splicing