Human Phosphorylated Alpha Synuclein ELISA Kit | PSNCA elisa kit

Human Phosphorylated Alpha Synuclein ELISA Kit

Cat. Num. AAA38716

• Gene Names: Snca; NACP; alphaSYN
• Reactivity: Human
• Synonyms: Phosphorylated Alpha Synuclein; Human Phosphorylated Alpha Synuclein ELISA Kit; PSNCA elisa kit

• Reactivity: Human

• Samples: Undiluted original human serum, plasma or tissue homogenates samples
• Detection Range: 3.12ng/ml-100ng/ml
• Sensitivity: 1.0ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 109638747
• NCBI GeneID: 20617
• NCBI Accession #: NP_001035916.1
• NCBI GenBank Nucleotide #: NM_001042451.1
• UniProt Accession #: O55042; Q3U130; Q9CXF8; Q9EQC3; Q9QUR3
• Molecular Weight: 14,485 Da
• NCBI Official Full Name: alpha-synuclein
• NCBI Official Synonym Full Names: synuclein, alpha
• NCBI Official Symbol: Snca
• NCBI Official Synonym Symbols: NACP; alphaSYN
• NCBI Protein Information: alpha-synuclein; alpha SYN; non-A4 component of amyloid; non-A beta component of AD amyloid
• UniProt Protein Name: Alpha-synuclein
• UniProt Gene Name: Snca
• UniProt Synonym Gene Names: Syn; NACP
• UniProt Entry Name: SYUA_MOUSE

Uniprot Description

SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; terminal button; inclusion body; cytosol; synaptic vesicle; platelet alpha granule membrane; perinuclear region of cytoplasm; cytoplasm; synapse; cytoplasmic vesicle membrane; rough endoplasmic reticulum; intracellular membrane-bound organelle; cell; fibril; cell cortex; actin cytoskeleton; growth cone; cytoskeleton; axon; plasma membrane; ribosome; nerve terminal; nucleus

Molecular Function: identical protein binding; zinc ion binding; histone binding; kinesin binding; ferrous iron binding; metal ion binding; magnesium ion binding; oxidoreductase activity; Hsp70 protein binding; calcium ion binding; enzyme binding; phospholipase binding; phospholipid binding; alpha-tubulin binding; protein domain specific binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; arachidonic acid binding; dynein binding; protein binding; copper ion binding; tau protein binding

Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; regulation of neurotransmitter secretion; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; dopamine metabolic process; positive regulation of neurotransmitter secretion; response to magnesium ion; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of neuronal synaptic plasticity; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; synaptic transmission, dopaminergic; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; negative regulation of monooxygenase activity; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of synaptic transmission; negative regulation of histone acetylation; negative regulation of dopamine uptake; synaptic transmission; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; response to iron(II) ion; positive regulation of receptor recycling; caspase activation; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of glutamate secretion; regulation of macrophage activation; synaptic vesicle transport; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential