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Proteasome alpha3 ELISA Kit | PSMC3 elisa kit

Proteasome alpha3 Colorimetric Cell-Based ELISA Kit

Gene Names
PSMC3; TBP1
Reactivity
Human, Mouse, Rat
Synonyms
Proteasome alpha3; Proteasome alpha3 Colorimetric Cell-Based ELISA Kit; 26S protease regulatory subunit 6A; proteasome subunit P50; PRS6A; TAT-binding protein 1; TBP-1; TBP1; PSMC3 elisa kit
Ordering
 
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For Research Use Only!
Reactivity
Human, Mouse, Rat
Form/Format
One 96-Well Plate
Sequence Length
439
Samples
Researchers plate their cell line of choice
Assay Type
Non-Phospho Cell-Based ELISA
Sensitivity
>=5000 cells/well
Detection Method
Colorimetric 450 nm
Preparation and Storage
Store at 4 degree C.
Product Categories/Family for PSMC3 elisa kit

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
49204
NCBI Official Full Name
26S proteasome regulatory subunit 6A
NCBI Official Synonym Full Names
proteasome 26S subunit, ATPase 3
NCBI Official Symbol
PSMC3
NCBI Official Synonym Symbols
TBP1
NCBI Protein Information
26S proteasome regulatory subunit 6A; 26S protease regulatory subunit 6A
UniProt Protein Name
26S proteasome regulatory subunit 6A
Protein Family
UniProt Gene Name
PSMC3
UniProt Synonym Gene Names
TBP1; TBP-1

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

Uniprot Description

RPT5: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, suppresses Tat-mediated transactivation. Belongs to the AAA ATPase family.

Protein type: Nuclear receptor co-regulator; Proteasome complex; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: cytosol; extracellular region; ficolin-1-rich granule lumen; membrane; nucleoplasm; nucleus; P-body; proteasome complex; proteasome regulatory particle, base subcomplex; secretory granule lumen

Molecular Function: ATP binding; ATPase activity; identical protein binding; proteasome-activating ATPase activity; protein binding; TATA-binding protein binding

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; blastocyst development; ER-associated protein catabolic process; Fc-epsilon receptor signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; neutrophil degranulation; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcriptional preinitiation complex assembly; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; post-translational protein modification; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mRNA stability; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; viral process; Wnt receptor signaling pathway, planar cell polarity pathway

Research Articles on PSMC3

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Product Notes

The Human, Mouse, Rat PSMC3 psmc3 (Catalog #AAA9500509) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500509 ELISA Kit recognizes Human, Mouse, Rat PSMC3. It is sometimes possible for the material contained within the vial of "Proteasome alpha3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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