Pregnancy-Specific beta-1-Glyco Protein 9/PSBG9 Recombinant Protein | PSBG9 recombinant protein

Recombinant Human Pregnancy-Specific beta-1-Glyco Protein 9/PSBG9 Protein (C-6His)

Cat. Num. AAA2553120

• Gene Names: PSG9; PS34; PSG11; PSGII; PSBG-9; PSBG-11
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Pregnancy-Specific beta-1-Glyco Protein 9/PSBG9; Recombinant Human Pregnancy-Specific beta-1-Glyco Protein 9/PSBG9 Protein (C-6His); Pregnancy-specific beta-1-glycoprotein 9; PS-beta-G-9; PSBG-9; Pregnancy-specific glycoprotein 9; PS34; Pregnancy-specific beta-1 glycoprotein B; PS-beta-B; Pregnancy-specific beta-1-glycoprotein 11; PS-beta-G-11; PSBG-11; Pregnancy-specific glycoprotein 11; Pregnancy-specific glycoprotein 7; PSG7; PSG11; PSBG9 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.5.
• Sequence Positions: Glu35-Ser426
• Sequence Length: 333

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for PSBG9 recombinant protein

Pregnancy-specific beta-1-glycoprotein 9(PSG9) is a secreted protein and contains 3 Ig-like C2-type (immunoglobulin-like) domains, 1 Ig-like V-type (immunoglobulin-like) domain. It is a member of the PSG family, a group of closely related secreted glycoproteins that are highly expressed in fetal placental syncytiotrophoblast cells. The members of the PSG protein family all have a characteristic N-terminal domain that is homologous to the immunoglobulin variable region. PSGs become detectable in serum during the first two to three weeks of pregnancy and increase as the pregnancy progresses, eventually representing the most abundant fetal protein in the maternal blood at term. PSGs function to stimulate secretion of TH2-type cytokines from monocytes, and they may also modulate the maternal immune system during pregnancy, thereby protecting the semi-allotypic fetus from rejection. PSGs are commonly expressed in trophoblast tumors. Eleven human PSG proteins (PSG1-PSG11) have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 683523955
• NCBI GeneID: 5678
• NCBI Accession #: NP_001288636.1
• NCBI GenBank Nucleotide #: NM_001301707.1
• UniProt Accession #: Q00887; Q15227; Q15236; Q15237; Q8WW78; Q9UQ73; B2R869
• Molecular Weight: Molecular Mass: 45.6 kDa; Actual Protein Molecular Mass: 65 kDa
• NCBI Official Full Name: pregnancy-specific beta-1-glycoprotein 9 isoform 2
• NCBI Official Synonym Full Names: pregnancy specific beta-1-glycoprotein 9
• NCBI Official Symbol: PSG9
• NCBI Official Synonym Symbols: PS34; PSG11; PSGII; PSBG-9; PSBG-11
• NCBI Protein Information: pregnancy-specific beta-1-glycoprotein 9
• UniProt Protein Name: Pregnancy-specific beta-1-glycoprotein 9
• UniProt Gene Name: PSG9
• UniProt Synonym Gene Names: PSG11; PS-beta-G-9; PSBG-9; Pregnancy-specific glycoprotein 9; PS-beta-B; PS-beta-G-11; PSBG-11; Pregnancy-specific glycoprotein 11; PSG7

NCBI Description

The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]