Phosphoserine Aminotransferase 1 Recombinant Protein | PSAT1 recombinant protein

Recombinant Human Phosphoserine Aminotransferase 1

Cat. Num. AAA144464

• Gene Names: PSAT1; PSA; EPIP; NLS2; PSAT; PSATD
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Phosphoserine Aminotransferase 1; Recombinant Human Phosphoserine Aminotransferase 1; PSAT1 Human; Phosphoserine Aminotransferase 1 Human Recombinant; Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; PSAT1; PSA; EPIP; PSAT1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: The PSAT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMDAPRQ VVNFGPGPAK LPHSVLLEIQ KELLDYKGVG ISVLEMSHRS SDFAKIINNT ENLVRELLAV PDNYKVIFLQ GGGCGQFSAV PLNLIGLKAG RCADYVVTGA WSAKAAEEAK KFGTINIVHP KLGSYTKIPD PSTWNLNPDA SYVYYCANET VHGVEFDFIP DVKGAVLVCD MSSNFLSKPV DVSKFGVIFA GAQKNVGSAG VTVVIVRDDL LGFALRECPS VLEYKVQAGN SSLYNTPPCF SIYVMGLVLE WIKNNGGAAA MEKLSSIKSQ TIYEIIDNSQ GFYVCPVEPQ NRSKMNIPFR IGNAKGDDAL EKRFLDKALE LNMLSLKGHR SVGGIRASLY NAVTIEDVQK LAAFMKKFLE MHQL.
• Sequence Length: 324

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze-thaw cycles.

Related Product Information for PSAT1 recombinant protein

Description: PSAT1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 394 amino acids (1-370) and having a molecular mass of 42.9kDa.PSAT1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Phosphoserine aminotransferase (PSAT1) catalyzes the conversion of 3-phosphohydroxypyruvate into 3-phosphoserine which is dephosphorylated consequently by phosphoserine phosphatase to form L-serine. PSAT1 is probably a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. PSAT1 is expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon. Defects in the PSAT1 gene are the cause of phosphoserine aminotransferase deficiency (PSATD). PSATD is distinguished biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.

Product Categories/Family for PSAT1 recombinant protein

Enzymes; Transferase

NCBI and Uniprot Product Information

• NCBI GI #: 10863955
• NCBI GeneID: 29968
• NCBI Accession #: NP_066977.1
• NCBI GenBank Nucleotide #: NM_021154.4
• UniProt Accession #: Q9Y617; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12
• NCBI Official Full Name: phosphoserine aminotransferase isoform 2
• NCBI Official Synonym Full Names: phosphoserine aminotransferase 1
• NCBI Official Symbol: PSAT1
• NCBI Official Synonym Symbols: PSA; EPIP; NLS2; PSAT; PSATD
• NCBI Protein Information: phosphoserine aminotransferase; endometrial progesterone-induced protein; phosphohydroxythreonine aminotransferase
• UniProt Protein Name: Phosphoserine aminotransferase
• Protein Family: Phosphoserine aminotransferase
• UniProt Gene Name: PSAT1
• UniProt Synonym Gene Names: PSA; PSAT
• UniProt Entry Name: SERC_HUMAN

NCBI Description

This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013]

Uniprot Description

PSAT1: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD). PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.6.1.52; Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - vitamin B6

Chromosomal Location of Human Ortholog: 9q21.2

Cellular Component: cytoplasm; cytosol

Molecular Function: phosphoserine transaminase activity; pyridoxal phosphate binding

Biological Process: L-serine biosynthetic process; pyridoxine biosynthetic process; amino acid biosynthetic process

Disease: Phosphoserine Aminotransferase Deficiency; Neu-laxova Syndrome 2