Hamster Presenilin 2 ELISA Kit | PS2 elisa kit

Hamster Presenilin 2 ELISA Kit

Cat. Num. AAA11334

• Gene Names: PSEN2; AD4; PS2; AD3L; STM2; CMD1V
• Reactivity: Hamster
• Synonyms: Presenilin 2; Hamster Presenilin 2 ELISA Kit; PS2 elisa kit

• Reactivity: Hamster

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 156105681
• NCBI GeneID: 5664
• NCBI Accession #: NP_036618.2
• NCBI GenBank Nucleotide #: NM_012486.2
• UniProt Accession #: P49810; Q96P32; A8K8D4; B1AP21
• Molecular Weight: 50,140 Da
• NCBI Official Full Name: presenilin-2 isoform 2
• NCBI Official Synonym Full Names: presenilin 2 (Alzheimer disease 4)
• NCBI Official Symbol: PSEN2
• NCBI Official Synonym Symbols: AD4; PS2; AD3L; STM2; CMD1V
• NCBI Protein Information: presenilin-2; AD5; E5-1; PS-2; AD3LP; STM-2
• UniProt Protein Name: Presenilin-2
• Protein Family: Inorganic pyrophosphatase
• UniProt Gene Name: PSEN2
• UniProt Synonym Gene Names: AD4; PS2; PSNL2; STM2; PS-2
• UniProt Entry Name: PSN2_HUMAN

NCBI Description

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

PSEN2: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified.

Protein type: Membrane protein, integral; Cell surface; Protease; Membrane protein, multi-pass; EC 3.4.23.-

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: Golgi apparatus; centrosome; cell surface; integral to plasma membrane; lysosomal membrane; nuclear inner membrane; cytosol; lipid raft; kinetochore; ciliary rootlet; membrane; cell soma; perinuclear region of cytoplasm; apical plasma membrane; mitochondrial inner membrane; dendritic shaft; neuromuscular junction; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cell cortex; Z disc; Golgi membrane; growth cone; axon; plasma membrane

Molecular Function: protein binding; endopeptidase activity; aspartic-type endopeptidase activity

Biological Process: positive regulation of catalytic activity; axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; protein maturation; regulation of synaptic plasticity; cell fate specification; positive regulation of coagulation; T cell receptor signaling pathway; T cell activation during immune response; amyloid precursor protein catabolic process; protein transport; hair follicle development; negative regulation of protein amino acid phosphorylation; beta-amyloid metabolic process; calcium ion transport; forebrain development; brain morphogenesis; ephrin receptor signaling pathway; negative regulation of protein binding; dorsoventral neural tube patterning; embryonic limb morphogenesis; cardiac muscle contraction; Notch signaling pathway; somitogenesis; membrane protein intracellular domain proteolysis; thymus development; regulation of epidermal growth factor receptor activity; membrane protein ectodomain proteolysis; Notch receptor processing; memory; endoplasmic reticulum calcium ion homeostasis; response to hypoxia; myeloid leukocyte differentiation; hemopoietic progenitor cell differentiation; protein processing; negative regulation of protein complex assembly; alveolus development; negative regulation of apoptosis

Disease: Alzheimer Disease 4; Cardiomyopathy, Dilated, 1v