Human PRP4 pre-mRNA processing factor 4 homolog B (yeast) ELISA Kit | PRPF4B elisa kit
Human Serine/threonine-protein kinase PRP4 homolog, PRPF4B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
Uniprot Description
PRP4: a kinase of the DYRK family associated with the spliceosome and the kinetochore. It binds pre-mRNA splicing factors SFRS8, PRP6 and pinin. It is an essential kinase that associates with both the U5 snRNP and the N-CoR deacetylase complexes. It may help coordinate pre-mRNA splicing with chromatin remodeling and transcriptional regulation. PRP4 has recently been shown to be a kinetochore component that is necessary to establish a functional spindle assembly checkpoint, and is necessary for recruitment or maintenance of the checkpoint proteins RPS27, MAD1, and MAD2 at the kinetochores.
Protein type: RNA splicing; Kinase, protein; Protein kinase, CMGC; Spliceosome; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; DYRK family; PRP4 subfamily
Chromosomal Location of Human Ortholog: 6p25.2
Cellular Component: nucleoplasm; chromosome
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity
Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; protein amino acid phosphorylation
Research Articles on PRPF4B
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Product Notes
The Human PRPF4B prpf4b (Catalog #AAA9324625) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324625 ELISA Kit recognizes Human PRPF4B. It is sometimes possible for the material contained within the vial of "PRP4 pre-mRNA processing factor 4 homolog B (yeast), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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