Testing Data
(Binding of CD275(ICOSL)trn-muIg +GAM/FITC to human HPB-MLT cells)
ICOS Ligand IgG2a Fc Fusion Protein
ICOS Ligand, Mouse IgG2a Fc Fusion Protein (Inducible T-cell Co-stimulator Ligand, ICOSL, ICOS-L, ICOSLG, B7 Homolog 2, B7H2, B7-H2, B7-like Protein Gl50, B7-related Protein 1, B7RP1, B7RP-1, CD275, GL50, KIAA0653, LICOS) (Biotin)
Applications
ELISA, Flow Cytometry, Functional Assay
Purity
PurifiedPurified by size exclusion.
Synonyms
ICOS Ligand IgG2a Fc Fusion Protein; ICOS Ligand; Mouse IgG2a Fc Fusion Protein (Inducible T-cell Co-stimulator Ligand; ICOSL; ICOS-L; ICOSLG; B7 Homolog 2; B7H2; B7-H2; B7-like Protein Gl50; B7-related Protein 1; B7RP1; B7RP-1; CD275; GL50; KIAA0653; LICOS) (Biotin); ICOS Ligand IgG2a Fc Fusion Protein protein
Purity/Purification
Purified
Purified by size exclusion.
Purified by size exclusion.
Form/Format
Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride, 0.2% BSA, 0.04% sodium azide, 5% glycerol. Labeled with Biotin.
Applicable Applications for ICOS Ligand IgG2a Fc Fusion Protein protein
ELISA (EL/EIA), Flow Cytometry (FC/FACS)
Application Notes
Suitable for use in ELISA and Flow Cytometry.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Testing Data
(Binding of CD275(ICOSL)trn-muIg +GAM/FITC to human HPB-MLT cells)
Testing Data
(Binding of CD275(ICOSL)trn-muIg +GAM/FITC to human HPB-MLT cells)
Related Product Information for ICOS Ligand IgG2a Fc Fusion Protein protein
The inducible costimulator CD278 (ICOS) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Unlike CD28, CD278 is only expressed on activated T cells. Secondary signaling through CD28 or CD278 results in discrete cytokine secretion profiles by the activated T cells (1). Engagement of CD152 (CTLA-4) anergizes cells costimulated with either CD28 and CD278 (2). Signaling through CD278 is particularly important in progression of TH2 immune response (5). The receptor for human CD278 (ICOS) is CD275 (GL50, ICOS L), a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2) (3). Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain (4). Blockade of the CD278-CD275 interaction in mice improves allograft survival (6) and reduces EAE (7).
Product Categories/Family for ICOS Ligand IgG2a Fc Fusion Protein protein
Similar Products
Product Notes
The ICOS Ligand IgG2a Fc Fusion Protein (Catalog #AAA634872) is a Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ICOS Ligand IgG2a Fc Fusion Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Flow Cytometry (FC/FACS). Suitable for use in ELISA and Flow Cytometry. Researchers should empirically determine the suitability of the ICOS Ligand IgG2a Fc Fusion Protein for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ICOS Ligand IgG2a Fc Fusion Protein, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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