Sequence Information
Parathyroid Hormone Related Protein (PTHrP) Small Molecule | PTHrP small molecule
OVA Conjugated Parathyroid Hormone Related Protein (PTHrP)
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Sequence Information
Sequence Information
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the parathyroid family of hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]
Uniprot Description
PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6 G3|6 78.19 cM
Cellular Component: cytoplasm; extracellular space; Golgi apparatus; intracellular; nucleoplasm
Molecular Function: hormone activity; peptide hormone receptor binding
Biological Process: alveolus development; bone mineralization; endochondral ossification; endoderm development; epithelial cell differentiation; G-protein signaling, adenylate cyclase activating pathway; negative regulation of chondrocyte differentiation; negative regulation of transcription factor activity; osteoblast development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; protein processing; regulation of gene expression; skeletal development; surfactant homeostasis
Research Articles on PTHrP
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Product Notes
The PTHrP pthlh (Catalog #AAA2086285) is a Small Molecule produced from Protein Conjugation and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Parathyroid Hormone Related Protein (PTHrP) can be used in a range of immunoassay formats including, but not limited to, Immunogen, SDS-PAGE, Western Blot (WB). Researchers should empirically determine the suitability of the PTHrP pthlh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Parathyroid Hormone Related Protein (PTHrP), Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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