Mouse CD201 ELISA Kit | PROCR elisa kit

Mouse CD201 ELISA Kit

Cat. Num. AAA8248454

• Gene Names: Procr; Ccca; Epcr; Ccd41; AI325044
• Reactivity: Mouse
• Synonyms: CD201; Mouse CD201 ELISA Kit; EPCR; Endothelial protein C receptor; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; PROCR elisa kit

• Reactivity: Mouse
• Specificity: The Mouse CD201 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Mouse CD201 proteins within the range of 156 pg/ml - 10000 pg/ml.
• Sequence Length: 242

• Samples: Cell Culture Supernates, Serum, Plasma
• Sensitivity: <15 pg/ml
• Preparation and Storage: Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for PROCR elisa kit

Principle of the Assay: The Mouse CD201 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Mouse CD201 in Cell Culture Supernates, Serum, Plasma. This assay employs an antibody specific for Mouse CD201 coated on a 96-well plate. Standards and samples are pipetted into the wells and CD201 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Mouse CD201 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of CD201 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

Background: Endothelial protein C receptor (EPCR), also known as CCCA or PROCR, is a protein that in humans is encoded by the PROCR gene. PRPCR gene is mapped to 20q11.2 by radiation hybrid analysis and FISH. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

NCBI and Uniprot Product Information

• NCBI GI #: 251823822
• NCBI GeneID: 19124
• NCBI Accession #: NP_035301.2
• NCBI GenBank Nucleotide #: NM_011171.2
• UniProt Accession #: Q64695; Q4FK76; Q9WV33
• Molecular Weight: 27,189 Da
• NCBI Official Full Name: endothelial protein C receptor
• NCBI Official Synonym Full Names: protein C receptor, endothelial
• NCBI Official Symbol: Procr
• NCBI Official Synonym Symbols: Ccca; Epcr; Ccd41; AI325044
• NCBI Protein Information: endothelial protein C receptor
• UniProt Protein Name: Endothelial protein C receptor
• Protein Family: Endothelial protein C receptor
• UniProt Gene Name: Procr
• UniProt Synonym Gene Names: Epcr; APC receptor
• UniProt Entry Name: EPCR_MOUSE

Uniprot Description

EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: cell surface; centrosome; focal adhesion

Molecular Function: protein C-terminus binding

Biological Process: negative regulation of coagulation