cGMP-dependent protein kinase 1 (Prkg1) Recombinant Protein | Prkg1 recombinant protein
Recombinant Mouse cGMP-dependent protein kinase 1 (Prkg1)
NCBI and Uniprot Product Information
Uniprot Description
Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates MRVI1/IRAG and inhibits IP3-induced Ca2+ release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca2+ levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle.
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Product Notes
The Prkg1 prkg1 (Catalog #AAA959027) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-671aa; Full Length of Mature Protein. The amino acid sequence is listed below: SELEEDFAKI LMLKEERIKE LEKRLSEKEE EIQELKRKLH KCQSVLPVPS THIGPRTTRA QGISAEPQTY RSFHDLRQAF RKFTKSERSK DLIKEAILDN DFMKNLELSQ IQEIVDCMYP VEYGKDSCII KEGDVGSLVY VMEDGKVEVT KEGVKLCTMG PGKVFGELAI LYNCTRTATV KTLVNVKLWA IDRQCFQTIM MRTGLIKHTE YMEFLKSVPT FQSLPDEILS KLADVLEETH YENGEYIIRQ GARGDTFFII SKGQVNVTRE DSPSEDPVFL RTLGKGDWFG EKALQGEDVR TANVIAAEAV TCLVIDRDSF KHLIGGLDDV SNKAYEDAEA KAKYEAEAAF FANLKLSDFN IIDTLGVGGF GRVELVQLKS EESKTFAMKI LKKRHIVDTR QQEHIRSEKQ IMQGAHSDFI VRLYRTFKDS KYLYMLMEAC LGGELWTILR DRGSFEDSTT RFYTACVVEA FAYLHSKGII YRDLKPENLI LDHRGYAKLV DFGFAKKIGF GKKTWTFCGT PEYVAPEIIL NKGHDISADY WSLGILMYEL LTGSPPFSGP DPMKTYNIIL RGIDMIEFPK KIAKNAANLI KKLCRDNPSE RLGNLKNGVK DIQKHKWFEG FNWEGLRKGT LTPPIIPSVA SPTDTSNFDS FPEDSDEPPP DDNSGWDIDF . It is sometimes possible for the material contained within the vial of "cGMP-dependent protein kinase 1 (Prkg1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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