Mouse cAMP-dependent protein kinase catalytic subunit alpha ELISA Kit | Prkaca elisa kit

Mouse cAMP-dependent protein kinase catalytic subunit alpha ELISA Kit

Cat. Num. AAA9427910

• Gene Names: Prkaca; PKCD; Pkaca
• Reactivity: Mouse
• Synonyms: cAMP-dependent protein kinase catalytic subunit alpha; Mouse cAMP-dependent protein kinase catalytic subunit alpha ELISA Kit; PKA C-alpha; Prkaca; Pkaca; 2.7.11.11; Prkaca elisa kit

• Reactivity: Mouse

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Detection Range: 0.312-20 ng/mL
• Assay Time: 3-5h
• Sample Volume: 100T
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 4 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 483968030
• NCBI GeneID: 18747
• NCBI Accession #: NP_001264827.1
• NCBI GenBank Nucleotide #: NM_001277898.1
• UniProt Accession #: P05132; Q9JID0
• Molecular Weight: 39,803 Da
• NCBI Official Full Name: cAMP-dependent protein kinase catalytic subunit alpha isoform 2
• NCBI Official Synonym Full Names: protein kinase, cAMP dependent, catalytic, alpha
• NCBI Official Symbol: Prkaca
• NCBI Official Synonym Symbols: PKCD; Pkaca
• NCBI Protein Information: cAMP-dependent protein kinase catalytic subunit alpha
• UniProt Protein Name: cAMP-dependent protein kinase catalytic subunit alpha
• Protein Family: cAMP-dependent protein kinase
• UniProt Gene Name: Prkaca
• UniProt Synonym Gene Names: Pkaca; PKA C-alpha

NCBI Description

This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]

Uniprot Description

PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.

Protein type: AGC group; EC 2.7.11.11; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 8|8 C2

Cellular Component: acrosome; AMP-activated protein kinase complex; cAMP-dependent protein kinase complex; centrosome; cytoplasm; cytosol; dendritic spine; Golgi apparatus; intercellular bridge; membrane; mitochondrion; neuromuscular junction; neuron projection; nuclear speck; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex

Molecular Function: ATP binding; cAMP-dependent protein kinase activity; magnesium ion binding; manganese ion binding; protein binding; protein complex binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; Rab GTPase binding; ubiquitin protein ligase binding

Biological Process: mesoderm formation; mRNA processing; negative regulation of meiotic cell cycle; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell proliferation; positive regulation of protein export from nucleus; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cellular respiration; regulation of osteoblast differentiation; regulation of synaptic transmission; regulation of synaptic transmission, glutamatergic; sperm capacitation