Rat prickle homolog 1 (Drosophila) ELISA Kit | PRICKLE1 elisa kit

Rat Prickle-like protein 1, PRICKLE1 ELISA Kit

Cat. Num. AAA9320449

• Gene Names: Prickle1; Rilp
• Reactivity: Rat
• Synonyms: prickle homolog 1 (Drosophila); Rat Prickle-like protein 1; PRICKLE1 ELISA Kit; Rat Prickle-like protein 1 (PRICKLE1) ELISA kit; EPM1B; FLJ31627; FLJ31937; MGC138902; MGC138903; RILP; REST (RE-1 silencing transcription factor) /NRSF (neuron-restrictive silencer factor) -interacting LIM domain protein; prickle homolog 1; prickle-l; PRICKLE1 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 90185250
• NCBI GeneID: 315259
• UniProt Accession #: Q71QF9
• Molecular Weight: 94,170 Da
• NCBI Official Full Name: Prickle-like protein 1
• NCBI Official Synonym Full Names: prickle homolog 1 (Drosophila)
• NCBI Official Symbol: Prickle1
• NCBI Official Synonym Symbols: Rilp
• NCBI Protein Information: prickle-like protein 1; prickle-like 1; REST/NRSF-interacting LIM domain protein 1
• UniProt Protein Name: Prickle-like protein 1
• Protein Family: Prickle-like protein
• UniProt Gene Name: Prickle1
• UniProt Synonym Gene Names: Rilp
• UniProt Entry Name: PRIC1_RAT

NCBI Description

plays a role in the nuclear localization of transcriptional regulators REST4 and REST/NRSF; may act as a nuclear receptor for transcription factors [RGD, Feb 2006]

Uniprot Description

PRICKLE1: Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. Defects in PRICKLE1 are the cause of progressive myoclonic epilepsy type 1B (EPM1B). EPM1B is an autosomal recessive disorder characterized by myoclonus that progresses in severity over time, tonic-clonic seizures and ataxia. Defects in PRICKLE1 may be a cause of susceptibility to neural tube defects (NTD). Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Belongs to the prickle / espinas / testin family.

Protein type: Unknown function

Cellular Component: nuclear membrane; nucleus; cytosol

Molecular Function: protein binding; zinc ion binding; transcription factor binding

Biological Process: positive regulation of protein ubiquitination; protein import into nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; neural tube closure; negative regulation of transcription, DNA-dependent