Mouse Apolipoprotein C2 Precursor ELISA Kit | PRE-APO-C2 elisa kit

Mouse Apolipoprotein C2 Precursor ELISA Kit

Cat. Num. AAA5791

• Gene Names: APOC2; APO-CII; APOC-II
• Reactivity: Mouse
• Synonyms: Apolipoprotein C2 Precursor; Mouse Apolipoprotein C2 Precursor ELISA Kit; PRE-APO-C2 elisa kit

• Reactivity: Mouse

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 32130518
• NCBI GeneID: 344
• NCBI Accession #: NP_000474.2
• NCBI GenBank Nucleotide #: NM_000483.4
• UniProt Accession #: P02655; Q9BS39; Q9UDE3; Q9UNK3; C0JYY4
• Molecular Weight: 11,284 Da
• NCBI Official Full Name: apolipoprotein C-II
• NCBI Official Synonym Full Names: apolipoprotein C-II
• NCBI Official Symbol: APOC2
• NCBI Official Synonym Symbols: APO-CII; APOC-II
• NCBI Protein Information: apolipoprotein C-II; apolipoprotein C2
• UniProt Protein Name: Apolipoprotein C-II
• UniProt Gene Name: APOC2
• UniProt Synonym Gene Names: APC2; Apo-CII; ApoC-II
• UniProt Entry Name: APOC2_HUMAN

NCBI Description

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Uniprot Description

APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; chylomicron; early endosome; extracellular region

Molecular Function: protein homodimerization activity; phospholipase binding; lipase inhibitor activity; lipid binding; phospholipase activator activity

Biological Process: positive regulation of fatty acid biosynthetic process; phototransduction, visible light; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; negative regulation of catalytic activity; positive regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; retinoid metabolic process; negative regulation of lipid metabolic process; lipid catabolic process

Disease: Apolipoprotein C-ii Deficiency