Histone-lysine N-methyltransferase PRDM9 (PRDM9) Recombinant Protein | PRDM9 recombinant protein

Recombinant Human Histone-lysine N-methyltransferase PRDM9 (PRDM9) , partial

• Gene Names: PRDM9; PFM6; KMT8B; MSBP3; ZNF899; MEISETZ
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Histone-lysine N-methyltransferase PRDM9 (PRDM9); Recombinant Human Histone-lysine N-methyltransferase PRDM9 (PRDM9); partial; PRDM9 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 894

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 872725204
• NCBI GeneID: 56979
• NCBI Accession #: NP_001297143.1
• NCBI GenBank Nucleotide #: NM_001310214.1
• UniProt Accession #: Q9NQV7; Q27Q50; B4DX22
• Molecular Weight: 103,376 Da
• NCBI Official Full Name: histone-lysine N-methyltransferase PRDM9 isoform PRDM9 A
• NCBI Official Synonym Full Names: PR/SET domain 9
• NCBI Official Symbol: PRDM9
• NCBI Official Synonym Symbols: PFM6; KMT8B; MSBP3; ZNF899; MEISETZ
• NCBI Protein Information: histone-lysine N-methyltransferase PRDM9
• UniProt Protein Name: Histone-lysine N-methyltransferase PRDM9
• Protein Family: Histone-lysine N-methyltransferase
• UniProt Gene Name: PRDM9
• UniProt Synonym Gene Names: PFM6

NCBI Description

The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]

Uniprot Description

Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase ().