PR domain zinc finger protein 8 (PRDM8) Recombinant Protein | PRDM8 recombinant protein

Recombinant Human PR domain zinc finger protein 8 (PRDM8)

Cat. Num. AAA1333302

• Gene Names: PRDM8; PFM5; EPM10; KMT8D
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: PR domain zinc finger protein 8 (PRDM8); Recombinant Human PR domain zinc finger protein 8 (PRDM8); PRDM8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-689, Full length protein
• Sequence: MEDTGIQRGIWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTVPYIFRVDTSAANGSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELLLLCPSRSHNKMNGSSPYTCLECSQRFQFEFPYVAHLRFRCPKRLHSADISPQDEQGGGVGTKDHGGGGGGGKDQQQQQQEAPLGPGPKFCKAGPLHHYPSPSPESSNPSAAAGGSSAKPSTDFHNLARELENSRGGSSCSPAQSLSSGSGSGGGGGHQEAELSPDGIATGGGKGKRKFPEEAAEGGGGAGLVGGRGRFVERPLPASKEDLVCTPQQYRASGSYFGLEENGRLFAPPSPETGEAKRSAFVEVKKAARAASLQEEGTADGAGVASEDQDAGGGGGSSTPAAASPVGAEKLLAPRPGGPLPSRLEGGSPARGSAFTSVPQLGSAGSTSGGGGTGAGAAGGAGGGQGAASDERKSAFSQPARSFSQLSPLVLGQKLGALEPCHPADGVGPTRLYPAAADPLAVKLQGAADLNGGCGSLPSGGGGLPKQSPFLYATAFWPKSSAAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPAQNWCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHLSRHMTSHN
• Sequence Length: 689

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 150378478
• NCBI GeneID: 56978
• NCBI Accession #: NP_001092873.1
• NCBI GenBank Nucleotide #: NM_001099403.1
• UniProt Accession #: Q9NQV8; Q6IQ36; A8K7X2
• Molecular Weight: 35,470 Da
• NCBI Official Full Name: PR domain zinc finger protein 8
• NCBI Official Synonym Full Names: PR/SET domain 8
• NCBI Official Symbol: PRDM8
• NCBI Official Synonym Symbols: PFM5; EPM10; KMT8D
• NCBI Protein Information: PR domain zinc finger protein 8
• UniProt Protein Name: PR domain zinc finger protein 8
• Protein Family: PR domain zinc finger protein
• UniProt Gene Name: PRDM8
• UniProt Synonym Gene Names: PFM5

NCBI Description

This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival ().