Mouse protein phosphatase 2 (formerly 2A) , regulatory subunit B, beta isoform ELISA Kit | PPP2R2B elisa kit
Mouse Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform, PPP2R2B ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PPP2R2B: the B regulatory subunit of PP2A. May modulate substrate selectivity and catalytic activity, and directs the localization of the catalytic enzyme to particular subcellular compartments. PPP2R2B promotes autophagy and oxidative stress induced cell death that is related to apoptosis. The PP2A holoenzyme consists of a common heterodimeric core enzyme composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (subunit A), that associates with a variety of regulatory subunits. Three families of regulatory subunits associate with the core dimmer: B (R2/PR55/B55), B¿ (R5/B56), and B¿ (R3/PR72/PR130/PR59). Five isoforms of the human protein are produced by alternative splicing. Isoform 1 (Bbeta1) localizes within the cytoplasm. Isoform 2 (Bbeta2) localizes to both cytosolic and mitochondrial compartments under basal conditions, relocating to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity. The N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal that is necessary and sufficient for targeting the PP2A holoenzyme to the OMM. The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that prevents PPP2R2B matrix translocation and signal sequence cleavage. Defects in PPP2R2B are the cause of spinocerebellar ataxia type 12 (SCA12).
Protein type: Mitochondrial; Apoptosis; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Cellular Component: mitochondrial outer membrane; protein phosphatase type 2A complex; cytoskeleton; mitochondrion; membrane; cytoplasm; cytosol
Molecular Function: protein complex binding; protein phosphatase type 2A regulator activity
Biological Process: mitochondrial fission; apoptosis; positive regulation of neuron apoptosis; regulation of protein phosphatase type 2A activity; mitochondrial fragmentation during apoptosis; signal transduction; protein targeting to mitochondrion
Research Articles on PPP2R2B
Similar Products
Product Notes
The Mouse PPP2R2B ppp2r2b (Catalog #AAA9321337) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321337 ELISA Kit recognizes Mouse PPP2R2B. It is sometimes possible for the material contained within the vial of "protein phosphatase 2 (formerly 2A) , regulatory subunit B, beta isoform, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
