Mouse protein phosphatase 2 (formerly 2A) , regulatory subunit A, alpha isoform ELISA Kit | PPP2R1A elisa kit
Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, PPP2R1A ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PPP2R1A: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction might decrease PP2A activity. Belongs to the phosphatase 2A regulatory subunit A family.
Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Cellular Component: protein phosphatase type 2A complex; cytoplasm; chromosome; cytosol; chromosome, pericentric region
Molecular Function: protein binding; protein heterodimerization activity; protein serine/threonine phosphatase activity; antigen binding
Biological Process: meiotic sister chromatid cohesion, centromeric; meiotic spindle elongation; female meiosis; mitotic sister chromatid separation; chromosome segregation
Research Articles on PPP2R1A
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Product Notes
The Mouse PPP2R1A ppp2r1a (Catalog #AAA9321398) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321398 ELISA Kit recognizes Mouse PPP2R1A. It is sometimes possible for the material contained within the vial of "protein phosphatase 2 (formerly 2A) , regulatory subunit A, alpha isoform, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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