Human protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF) , interacting protein (liprin) , alpha 2 ELISA Kit | PPFIA2 elisa kit
Human Liprin-alpha-2, PPFIA2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Description
liprin alpha 2: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Belongs to the liprin family. Liprin-alpha subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 12q21.31
Cellular Component: cell surface; cytoplasm; presynaptic active zone; cytosol
Molecular Function: protein binding; protein complex binding
Biological Process: synaptic transmission; glutamate secretion; cell-matrix adhesion; neurotransmitter secretion
Research Articles on PPFIA2
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Product Notes
The Human PPFIA2 ppfia2 (Catalog #AAA9335417) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335417 ELISA Kit recognizes Human PPFIA2. It is sometimes possible for the material contained within the vial of "protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF) , interacting protein (liprin) , alpha 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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