Human peroxisome proliferator-activated receptor gamma, coactivator 1 beta ELISA Kit | PPARGC1B elisa kit
Human Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PPARGC1B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Description
PGC-1 beta: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: nucleoplasm; mitochondrion; Srb-mediator complex; nucleus
Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; AF-2 domain binding; RNA binding; nucleotide binding; estrogen receptor binding; transcription factor binding; receptor activator activity
Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; ossification; response to cAMP; estrogen receptor signaling pathway; positive regulation of osteoclast differentiation; organelle organization and biogenesis; response to glucocorticoid stimulus; actin filament organization; cellular lipid metabolic process; transcription from mitochondrial promoter; regulation of transcription, DNA-dependent; positive regulation of bone resorption; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation
Disease: Obesity
Research Articles on PPARGC1B
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Product Notes
The Human PPARGC1B ppargc1b (Catalog #AAA9333795) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333795 ELISA Kit recognizes Human PPARGC1B. It is sometimes possible for the material contained within the vial of "peroxisome proliferator-activated receptor gamma, coactivator 1 beta, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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