Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ELISA Kit | Ppargc1a elisa kit
Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Uniprot Description
PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5|5 C1
Cellular Component: cell soma; cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: alpha-tubulin binding; chromatin binding; chromatin DNA binding; DNA binding; estrogen receptor binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; peroxisome proliferator activated receptor binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding
Biological Process: circadian regulation of gene expression; mitochondrion organization and biogenesis; negative regulation of glycolysis; negative regulation of neuron apoptosis; negative regulation of protein amino acid phosphorylation; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; positive regulation of cellular metabolic process; positive regulation of fatty acid oxidation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; regulation of transcription, DNA-dependent; response to activity; response to dietary excess; response to muscle activity
Research Articles on Ppargc1a
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Product Notes
The Mouse Ppargc1a ppargc1a (Catalog #AAA9426693) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9426693 ELISA Kit recognizes Mouse Ppargc1a. It is sometimes possible for the material contained within the vial of "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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