TPCN1 positive control
TPCN1 Antibody Positive Control
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal and endosomal membrane.
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Uniprot Description
TPCN1: one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane. Highest expression found in the heart and kidney, and lowest expression found in the spleen. Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. Two alternatively spliced human isoforms have been described.
Protein type: Transporter; Membrane protein, integral; Channel, calcium; Transporter, ion channel; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component: endosome; endosome membrane; integral to membrane; lysosomal membrane; lysosome; plasma membrane
Molecular Function: identical protein binding; protein binding; voltage-gated calcium channel activity
Biological Process: positive regulation of autophagy; release of sequestered calcium ion into cytosol
Research Articles on TPCN1
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Product Notes
The TPCN1 tpcn1 (Catalog #AAA543342) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TPCN1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the TPCN1 tpcn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPCN1, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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