SOCS1 positive control
SOCS1 Positive Control
Applications
Western Blot
Synonyms
SOCS1; SOCS1 Positive Control; CISH 1; Cytokine Inducible SH2 Protein 1; JAB; JAK-binding protein; Janus kinase binding protein; SOCS-1; SSI1; STAT Induced STAT Inhibitor 1; Suppressor of cytokine signaling 1; TEC Interacting Protein 3; TIP3 antibody; SOCS1 positive control
Form/Format
Western Blot Positive Control
Sequence Length
98
Applicable Applications for SOCS1 positive control
Western Blot (WB)
Application Notes
Western Blot: 1:500
Immunogen
Purified Protein
Expression
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Molecular Function
Insulin-like growth factor receptor binding; Protein kinase binding; Kinase inhibitor activity
Structure
Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC (SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with AXL, CUL2 and FGFR3. Interacts with INSR.
Subcellular Location
Nucleus; Cytoplasmic vesicle
Preparation and Storage
-20 degree C for long term storage
Related Product Information for SOCS1 positive control
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
11,267 Da
NCBI Official Full Name
unnamed protein product
UniProt Protein Name
Capsid assembly scaffolding protein
Protein Family
UniProt Gene Name
7
UniProt Synonym Gene Names
gp7Curated
UniProt Entry Name
SCAF_BPPH2
Uniprot Description
Scaffolding protein involved in the icosahedric procapsid assembly. Coassembles with the capsid proteins to form the procapsid. The scaffolding protein is found within the capsid as a serie of concentric shells. During DNA packaging, the scaffolding protein molecules are released from the procapsid.
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Product Notes
The SOCS1 7 (Catalog #AAA543273) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SOCS1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the SOCS1 7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS1, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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