P2Y2 positive control
P2Y2 Positive Control
Related Products: Antigenic Blocking Peptide: MBS544096
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Uniprot Description
P2Y2: a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, misc.; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q13.5-q14.1
Cellular Component: apical plasma membrane; basolateral plasma membrane; cytosol; early endosome; integral to plasma membrane; lysosome; mitochondrion; plasma membrane
Molecular Function: ATP binding; purinergic nucleotide receptor activity, G-protein coupled; receptor activity; UTP-activated nucleotide receptor activity
Biological Process: aging; cellular ion homeostasis; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); in utero embryonic development; negative regulation of ossification; positive regulation of chemokine production; positive regulation of prostaglandin secretion; positive regulation of smooth muscle cell migration; regulation of vasodilation; sensory perception of pain; wound healing
Research Articles on P2Y2
Similar Products
Product Notes
The P2Y2 p2ry2 (Catalog #AAA543018) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's P2Y2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500 Related Products: Antigenic Blocking Peptide: MBS544096. Researchers should empirically determine the suitability of the P2Y2 p2ry2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P2Y2, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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