MAP3K14 positive control
MAP3K14 Antibody Western Blot Positive Control
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Uniprot Description
Nik: a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Protein type: Kinase, protein; Protein kinase, STE; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; cytosol
Molecular Function: ATP binding; kinase activity; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of MAPKK activity; I-kappaB kinase/NF-kappaB cascade; immune response; MAPKKK cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell costimulation; tumor necrosis factor-mediated signaling pathway
Research Articles on MAP3K14
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Product Notes
The MAP3K14 map3k14 (Catalog #AAA542933) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MAP3K14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the MAP3K14 map3k14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAP3K14, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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