LIM kinase 2 Positive Control | LIM positive control

LIM kinase 2 Positive Control

Gene Names

KDM4C; GASC1; JHDM3C; JMJD2C; TDRD14C

Applications

Western Blot

Synonyms

LIM kinase 2; LIM kinase 2 Positive Control; LIM domain kinase 2; LIMK 2 antibody; LIM positive control

Ordering
Cat. Num. AAA542918 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Form/Format

Western Blot Positive Control

Sequence Length

1056

Applicable Applications for LIM positive control

Western Blot (WB)

Application Notes

Western Blot: 1:500

Immunogen

Purified Protein

Expression

Overexpressed in several esophageal squamous cell carcinomas (ESCs).

Molecular Function

Androgen receptor binding, enzyme binding, histone demethylase activity, zinc ion binding, dioxygenase activity

Subcellular Location

Nucleus

Preparation and Storage

-20 degree C for long term storage

Related Product Information for LIM positive control

Western Blot Positive Control Lysine-specific demethylase 4C
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code

NCBI and Uniprot Product Information

NCBI GI #

97536525

NCBI GeneID

23081

UniProt Accession #

Q9H3R0; O94877; Q2M3M0; Q5JUC9; Q5VYJ2; Q5VYJ3; B4E1Y4; B7ZL46; F5H347; F5H7P0

Molecular Weight

94,376 Da

NCBI Official Full Name

Lysine-specific demethylase 4C

NCBI Official Synonym Full Names

lysine demethylase 4C

NCBI Official Symbol

KDM4C

NCBI Official Synonym Symbols

GASC1; JHDM3C; JMJD2C; TDRD14C

NCBI Protein Information

lysine-specific demethylase 4C

UniProt Protein Name

Lysine-specific demethylase 4C

UniProt Gene Name

KDM4C

UniProt Synonym Gene Names

GASC1; JHDM3C; JMJD2C; KIAA0780; GASC-1 protein

UniProt Entry Name

KDM4C_HUMAN

NCBI Description

This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Description

JMJD2C: the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. Preferentially expressed in undifferentiated ES cells. JMJD2C, along with JMJD1A, regulate self-renewal in embryonic stem cells. Specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Two isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: nuclear chromatin; nucleoplasm

Molecular Function: androgen receptor binding; dioxygenase activity; enzyme binding; histone demethylase activity; histone demethylase activity (H3-K9 specific); zinc ion binding

Biological Process: histone H3-K9 demethylation; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent

Research Articles on LIM

1. Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions

Similar Products

Product Notes

The LIM kdm4c (Catalog #AAA542918) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's LIM kinase 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the LIM kdm4c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LIM kinase 2, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...

LIM kinase 2 Positive Control | LIM positive control