DYRK1 positive control

DYRK1 Positive Control

Cat. Num. AAA5400701

• Gene Names: DYRK1A; MNB; DYRK; HP86; MNBH; MRD7; DYRK1
• Applications: Western Blot
• Purity: Immobilized antigen affinity chromatography
• Synonyms: DYRK1; DYRK1 Positive Control; Western Blot Positive Control Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody; Dual specificity tyrosine phosphorylation regulated kinase; Dual specificity YAK1-related kinase; DYRK; DYRKA; hMNB; HP86; Minibrain; Drosophila; homolog of; MNB; MNB protein kinase; Mnb protein kinase homolog hp86; Serine/threonine-specific; MNB/DYRK protein kinase; MNBH; MRD7; Protein kinase minibrain homolog; Serine/threonine kinase MNB; DYRK1 positive control

• Purity/Purification: Immobilized antigen affinity chromatography
• Sequence Length: 754

• Applicable Applications for DYRK1 positive control: Western Blot (WB)
• Application Notes: WB: 1:500
• Immunogen: Purified protein
• Molecular Function: Kinase; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase
• Subcellular Location: Nucleus Speckle
• Preparation and Storage: Store at -20 degree C for long term storage.

Related Product Information for DYRK1 positive control

Overview: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3

Structure: The polyhistidine repeats act as targeting signals to nuclear speckles.

Expression: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

NCBI and Uniprot Product Information

• NCBI GI #: 1113820495
• NCBI GeneID: 1859
• NCBI Accession #: NP_001334650.1
• NCBI GenBank Nucleotide #: NM_001347721.1
• UniProt Accession #: Q13627; O60769; Q92582; Q92810; Q9UNM5
• Molecular Weight: 66,099 Da
• NCBI Official Full Name: dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2
• NCBI Official Synonym Full Names: dual specificity tyrosine phosphorylation regulated kinase 1A
• NCBI Official Symbol: DYRK1A
• NCBI Official Synonym Symbols: MNB; DYRK; HP86; MNBH; MRD7; DYRK1
• NCBI Protein Information: dual specificity tyrosine-phosphorylation-regulated kinase 1A
• UniProt Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A
• Protein Family: Probable serine/threonine-protein kinase
• UniProt Gene Name: DYRK1A
• UniProt Synonym Gene Names: DYRK; MNB; MNBH; MNBH; hMNB

NCBI Description

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis ().