CCR4 positive control

CCR4 Antibody Positive Control

Cat. Num. AAA542607

• Gene Names: CCR4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099
• Applications: Western Blot
• Synonyms: CCR4; CCR4 Antibody Positive Control; CD194; ChemR13; CKR4; CMKBR 4; HGCN 14099; K5 5 antibody; CCR4 positive control

• Form/Format: Western Blot Positive Control
• Sequence Length: 360

• Applicable Applications for CCR4 positive control: Western Blot (WB)
• Application Notes: Western Blot: 1:500
• Immunogen: Purified Protein
• Expression: Thymus, peripheral blood leukocytes including T-cells, CD4+ cells, basophils and in platelets. Expressed less in spleen and in monocytes. Also found in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expresseding cutaneous lymphocyte antigen. Expressed in brain and microvascular and coronary artery endothelial cells.
• Molecular Function: GPCR, Receptor, Transducer.
• Structure: Belongs to G-protein coupled receptor 1 family. Interacts with CREB3.
• Subcellular Location: Cell membrane; Multi-pass membrane protein
• Preparation and Storage: -20 degree C for long term storage

Western Blot (WB)

Related Product Information for CCR4 positive control

Western Blot Positive Control C-C chemokine receptor type 4 Antibody
Receptor for C-C type chemokines CCL17/TARC and CCL22/MDC. Functions as chemoattractant homing receptor on circulating memory lymphocytes and as coreceptor for some primary HIV-2 isolates. Can also mediate hippocampal-neuron survival.

NCBI and Uniprot Product Information

• NCBI GI #: 5031627
• NCBI GeneID: 1233
• NCBI Accession #: NP_005499
• NCBI GenBank Nucleotide #: NM_005508.4
• UniProt Accession #: P51679; Q9ULY6; Q9ULY7
• Molecular Weight: 41,403 Da
• NCBI Official Full Name: C-C chemokine receptor type 4
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 4
• NCBI Official Symbol: CCR4
• NCBI Official Synonym Symbols: CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099
• NCBI Protein Information: C-C chemokine receptor type 4
• UniProt Protein Name: C-C chemokine receptor type 4
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR4
• UniProt Synonym Gene Names: CMKBR4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4
• UniProt Entry Name: CCR4_HUMAN

NCBI Description

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Uniprot Description

CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p24

Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; homeostasis of number of cells; immune response; inflammatory response; neuron migration; tolerance induction