Porcine Transforming Growth Factor Beta 1 (TGFb1) ELISA Kit | TGFb1 elisa kit

Porcine Transforming Growth Factor Beta 1 (TGFb1) ELISA Kit

Cat. Num. AAA451173

• Gene Names: TGFB1; TGF-BETA-1
• Reactivity: Porcine
• Synonyms: Transforming Growth Factor Beta 1 (TGFb1); Porcine Transforming Growth Factor Beta 1 (TGFb1) ELISA Kit; TGF-B1; CED; DPD1; LAP; Camurati-Engelmann Disease; Latency-associated peptide; TGFb1 elisa kit

• Reactivity: Porcine
• Sequence Length: 390

• Samples: Serum, platelet-poor plasma, tissue homogenates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 31.25-2000pg/mL
• Sensitivity: 10.5pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 55741797
• NCBI GeneID: 397078
• NCBI Accession #: NP_999180.1
• NCBI GenBank Nucleotide #: NM_214015.1
• UniProt Accession #: P07200; P08832
• Molecular Weight: 44,294 Da
• NCBI Official Full Name: transforming growth factor beta-1
• NCBI Official Symbol: TGFB1
• NCBI Official Synonym Symbols: TGF-BETA-1
• NCBI Protein Information: transforming growth factor beta-1
• UniProt Protein Name: Transforming growth factor beta-1
• Protein Family: Transforming growth factor
• UniProt Gene Name: TGFB1
• UniProt Synonym Gene Names: TGF-beta-1; LAP

Uniprot Description

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types ().