Typical Testing Data/Standard Curve (for reference only)
Porcine Growth Hormone Receptor (GHR) ELISA Kit | GHR elisa kit
Pig Growth Hormone Receptor (GHR) ELISA Kit
No significant cross-reactivity or interference between Growth Hormone Receptor (GHR) and analogues was observed.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Uniprot Description
GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5p13.1-p12
Cellular Component: cell surface; cytoplasmic ribonucleoprotein granule; cytosol; extracellular region; extracellular space; integral component of membrane; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; peptide hormone binding; proline-rich region binding; protein binding; protein homodimerization activity; protein kinase binding
Biological Process: 2-oxoglutarate metabolic process; activation of JAK protein; activation of MAPK activity; allantoin metabolic process; cellular response to hormone stimulus; citrate metabolic process; creatine metabolic process; creatinine metabolic process; cytokine-mediated signaling pathway; endocytosis; fatty acid metabolic process; insulin-like growth factor receptor signaling pathway; isoleucine metabolic process; JAK-STAT cascade; multicellular organism metabolic process; oxaloacetate metabolic process; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of multicellular organism growth; succinate metabolic process; taurine metabolic process; valine metabolic process
Disease: Hypercholesterolemia, Familial; Laron Syndrome
Research Articles on GHR
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Product Notes
The Porcine GHR ghr (Catalog #AAA2097941) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2097941 ELISA Kit recognizes Porcine GHR. It is sometimes possible for the material contained within the vial of "Growth Hormone Receptor (GHR), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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