Porcine Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) ELISA Kit | CPSF6 elisa kit
Porcine Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Uniprot Description
CPSF6: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping. Belongs to the RRM CPSF6/7 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Spliceosome; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: nucleoplasm; membrane; paraspeckles; nucleus; ribonucleoprotein complex; mRNA cleavage factor complex
Molecular Function: mRNA binding; protein binding; RNA binding; nucleotide binding
Biological Process: mRNA polyadenylation; mRNA processing; protein tetramerization