Porcine Centromere Protein R (ITGB3BP) ELISA Kit | ITGB3BP elisa kit

Porcine Centromere Protein R (ITGB3BP) ELISA Kit

Cat. Num. AAA7260748

• Gene Names: ITGB3BP; CENPR; NRIF3; TAP20; CENP-R; HSU37139
• Reactivity: Porcine
• Synonyms: Centromere Protein R (ITGB3BP); Porcine Centromere Protein R (ITGB3BP) ELISA Kit; ITGB3BP elisa kit

• Reactivity: Porcine
• Sequence Length: 177

• Reproducibility: Intra-Assay: CV<10%; Inter-Assay: CV<15%
• Reactivity Note: No significant cross-reactivity or interference between this antigen and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection, therefore, cross reaction may still exist in some cases.
• Preparation and Storage: Store at 2-8 degree C.; The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

Related Product Information for ITGB3BP elisa kit

This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets.

Product Categories/Family for ITGB3BP elisa kit

Epigenetics and Nuclear Signaling; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 27597075
• NCBI GeneID: 23421
• NCBI Accession #: NP_055103.3
• NCBI GenBank Nucleotide #: NM_014288.4
• UniProt Accession #: Q13352; Q13353; Q5RJ42; Q5RJ44; Q5RJ45; Q7KYX2; Q96CD5; Q9UKB6; B2R7D8
• Molecular Weight: 19,302 Da
• NCBI Official Full Name: centromere protein R isoform 2
• NCBI Official Synonym Full Names: integrin subunit beta 3 binding protein
• NCBI Official Symbol: ITGB3BP
• NCBI Official Synonym Symbols: CENPR; NRIF3; TAP20; CENP-R; HSU37139
• NCBI Protein Information: centromere protein R
• UniProt Protein Name: Centromere protein R
• Protein Family: Centromere protein
• UniProt Gene Name: ITGB3BP
• UniProt Synonym Gene Names: CENPR; NRIF3; CENP-R

NCBI Description

This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Uniprot Description

Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.