SDS-PAGE
NADPH--cytochrome P450 reductase (POR) Recombinant Protein | POR recombinant protein
Recombinant Human NADPH--cytochrome P450 reductase (POR), partial
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Uniprot Description
POR: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Defects in POR are the cause of Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis (ABS1). A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. Defects in POR are the cause of disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD). A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
Protein type: Oxidoreductase; EC 1.6.2.4
Chromosomal Location of Human Ortholog: 7q11.2
Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrion; intracellular membrane-bound organelle
Molecular Function: protein binding; enzyme binding; electron carrier activity; FAD binding; hydrolase activity; FMN binding; NADPH-hemoprotein reductase activity; nitric oxide dioxygenase activity; cytochrome-b5 reductase activity; iron ion binding; NADP binding; iron-cytochrome-c reductase activity
Biological Process: response to drug; nitric oxide catabolic process; internal peptidyl-lysine acetylation; positive regulation of monooxygenase activity; positive regulation of cholesterol biosynthetic process; negative regulation of caspase activity; negative regulation of lipase activity; nitrate catabolic process; positive regulation of chondrocyte differentiation; flavonoid metabolic process; positive regulation of smoothened signaling pathway; fatty acid oxidation; carnitine metabolic process; response to nutrient
Disease: Disordered Steroidogenesis Due To Cytochrome P450 Oxidoreductase Deficiency; Antley-bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis; Antley-bixler Syndrome Without Genital Anomalies Or Disordered Steroidogenesis
Research Articles on POR
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Product Notes
The POR por (Catalog #AAA967255) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-671aa; Partial of BC034277. The amino acid sequence is listed below: INMGDSHVDT SSTVSEAVAE EVSLFSMTDM ILFSLIVGLL TYWFLFRKKK EEVPEFTKIQ TLTSSVRESS FVEKMKKTGR NIIVFYGSQT GTAEEFANRL SKDAHRYGMR GMSADPEEYD LADLSSLPEI DNALVVFCMA TYGEGDPTDN AQDFYDWLQE TDVDLSGVKF AVFGLGNKTY EHFNAMGKYV DKRLEQLGAQ RIFELGLGDD DGNLEEDFIT WREQFWLAVC EHFGVEATGE ESSIRQYELV VHTDIDAAKV YMGEMGRLKS YENQKPPFDA KNPFLAAVTT NRKLNQGTER HLMHLELDIS DSKIRYESGD HVAVYPANDS ALVNQLGKIL GADLDVVMSL NNLDEESNKK HPFPCPTSYR TALTYYLDIT NPPRTNVLYE LAQYASEPSE QELLRKMASS SGEGKELYLS WVVEARRHIL AILQDCPSLR PPIDHLCELL PRLQARYYSI ASSSKVHPNS VHICAVVVEY ETKAGRINKG VATNWLRAKE PVGENGGRAL VPMFVRKSQF RLPFKATTPV IMVGPGTGVA PFIGFIQERA WLRQQGKEVG ETLLYYGCRR SDEDYLYREE LAQFHRDGAL TQLNVAFSRE QSHKVYVQHL LKQDREHLWK LIEGGAHIYV CGDARNMARD VQNTFYDIVA ELGAMEHAQA VDYIKKLMTK . It is sometimes possible for the material contained within the vial of "NADPH--cytochrome P450 reductase (POR), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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