Western Blot (WB)
(Western blot analysis of ZNF9 Antibody (Center) in Neuro-2a cell line lysates (35ug/lane). ZNF9 (arrow) was detected using the purified Pab.)
Rabbit ZNF9 Polyclonal Antibody | anti-CNBP antibody
ZNF9 Antibody (Center)
Western Blot (WB)
(Western blot analysis of ZNF9 Antibody (Center) in Neuro-2a cell line lysates (35ug/lane). ZNF9 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of ZNF9 Antibody (Center) in Neuro-2a cell line lysates (35ug/lane). ZNF9 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(ZNF9 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZNF9 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(ZNF9 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZNF9 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Auvinen, S., et al. Arthritis Rheum. 58(11):3627-3631(2008)
Gerbasi, V.R., et al. Mol. Cell Proteomics 6(6):1049-1058(2007)
Toth, C., et al. Muscle Nerve 35(2):259-264(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ZNF9: Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression. Defects in CNBP are the cause of dystrophia myotonica type 2 (DM2); also known as proximal myotonic myopathy (PROMM). A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding; RNA-binding
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: endoplasmic reticulum; nucleus; cytosol
Molecular Function: protein binding; single-stranded RNA binding; zinc ion binding; transcription factor activity; single-stranded DNA binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; cholesterol biosynthetic process
Disease: Myotonic Dystrophy 2
Research Articles on CNBP
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Product Notes
The CNBP cnbp (Catalog #AAA9204859) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 67-96. The ZNF9 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Chicken, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's ZNF9 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CNBP cnbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZNF9, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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