Rabbit ZNF423 Polyclonal Antibody | anti-ZNF423 antibody
ZNF423 Antibody
Gene Names
ZNF423; OAZ; Roaz; Ebfaz; JBTS19; NPHP14; ZFP423; Zfp104
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
ZNF423; Polyclonal Antibody; ZNF423 Antibody; Early B cell factor associated zinc finger protein; Ebfaz; hOAZ; JBTS19; KIAA0760; NPHP14; Nur12; OAZ; OLF 1/EBF associated zinc finger; OLF1/EBF associated zinc finger protein; Olf1/EBF-associated zinc finger protein; Roaz; Smad and Olf interacting zinc finger protein; Smad- and Olf-interacting zinc finger protein; Zfp104; ZFP423; zinc finger protein 423; mouse; homolog of; Zinc finger protein 423; ZN423_HUMAN; ZNF423 zinc finger protein 423; anti-ZNF423 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
ZNF423 Antibody detects endogenous levels of ZNF423.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ZNF423 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human ZNF423.
Conjugation
Unconjugated
Similarity
Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and Olf signaling pathways. C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 and SMAD4, while zinc fingers 28-30 mediate the interaction with EBF1. zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1, while zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs. Belongs to the krueppel C2H2-type zinc-finger protein family.
Subunit Structure
Homodimer (By similarity). Interacts with EBF1 (By similarity). Interacts with SMAD1 and SMAD4. Interacts with PARP1. Interacts with CEP290.
Tissue Specificity
Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum.
Function
Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
144,605 Da
NCBI Official Full Name
zinc finger protein 423 isoform 2
NCBI Official Synonym Full Names
zinc finger protein 423
NCBI Official Symbol
ZNF423
NCBI Official Synonym Symbols
OAZ; Roaz; Ebfaz; JBTS19; NPHP14; ZFP423; Zfp104
NCBI Protein Information
zinc finger protein 423; hOAZ; OLF-1/EBF associated zinc finger; olf1/EBF-associated zinc finger protein; Smad- and Olf-interacting zinc finger protein; early B-cell factor associated zinc finger protein
UniProt Protein Name
Zinc finger protein 423
Protein Family
UniProt Gene Name
ZNF423
UniProt Synonym Gene Names
KIAA0760; NPHP14; OAZ; hOAZ
UniProt Entry Name
ZN423_HUMAN
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Product Notes
The ZNF423 znf423 (Catalog #AAA9630671) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZNF423 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ZNF423 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the ZNF423 znf423 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZNF423, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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