Western Blot (WB)
(ZNF274 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ZNF274 antibody detected the ZNF274 protein (arrow).)
Rabbit ZNF274 Polyclonal Antibody | anti-ZNF274 antibody
ZNF274 Antibody (N-term)
Western Blot (WB)
(ZNF274 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ZNF274 antibody detected the ZNF274 protein (arrow).)
Western Blot (WB)
(ZNF274 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ZNF274 antibody detected the ZNF274 protein (arrow).)
C2H2-type zinc finger domains, one or two Kruppel-associated box A
(KRAB A) domains, and a leucine-rich domain. The encoded protein
has been suggested to be a transcriptional repressor. It localizes
predominantly to the nucleolus. Alternatively spliced transcript
variants encoding different isoforms exist. These variants utilize
alternative polyadenylation signals.
Sripathy, S.P., et al. Mol. Cell. Biol. 26(22):8623-8638(2006)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Yano, K., et al. Genomics 65(1):75-80(2000)
Casademunt, E., et al. EMBO J. 18(21):6050-6061(1999)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
Uniprot Description
ZNF274: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. Belongs to the krueppel C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; Nucleolus; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 19qter
Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity; transcription corepressor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on ZNF274
Similar Products
Product Notes
The ZNF274 znf274 (Catalog #AAA9208084) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 53-82. The ZNF274 Antibody (N-term) reacts with Human (Predicted Reactivity: Monkey) and may cross-react with other species as described in the data sheet. AAA Biotech's ZNF274 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ZNF274 znf274 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZNF274, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
